Endocrine Abstracts

Gonadotroph adenomas are usually detected by their local mass effects. Spontaneous ovarian hyperstimulation syndrome (OHS) has rarely been described as the main manifestation of gonadotroph adenomas in young women. We present a case with a prolonged OHS occurring during IVF ovarian induction leading to the discovery of a FSH pituitary tumour.Case report: A 36 year-old, normal weight woman with 2 years primary infertility linked to oligomenorrhea and anov...

Adiponectin is a protein hormone mainly produced by adipocytes. It plays an essential role in the regulation of lipid and carbohydrate metabolisms. Adiponectin mediates its effects through mainly two receptors named AdipoR1 and AdipoR2. Some evidence in rodent and domestic animals suggests that adiponectin could also regulate female fertility and more particularly ovarian functions. However, its role in human ovary has never been investigated. The objectives of the present stu...

Adiponectin is one of the most abundant fat-derived hormones involved in a multitude of metabolism pathways. It acts as an anti-diabetic and anti-atherogenic adipokine. Adiponectin mediates its actions through mainly two receptors, AdipoR1 and AdipoR2. It has been postulated that although AdipoR1 and AdipoR2 consist of seven transmembrane helices, they are distinct from other G protein-coupled receptors. A role of adiponectin in ovarian physiology has been recently suggested. ...

A 72-year-old depressed woman complained about fatigue, weight gain (20 kilos/2 years), severe and recent hypertension, easy bruises, and venous insufficiency. Whereas she was treated with six antihypertensive drugs, she had hypokaliemia (2.6 mM). Cardiac ultrasounds showed myocardial hypertrophy. A Cushing syndrome was suspected. UFC was increased (400 mM/d), cortisol cycle disrupted and a standard DXM test showed no cortisol suppression (775 nM/l). ACTH levels were consisten...

A 61-year-old man was hospitalized for paresthesias and renal insufficiency (creatinine clearance 24 ml/min) with proteinuria. Type 2 diabetes was diagnosed in 2003 and hypertension in 2007. Hypercalcemia (4.6 mM) with normal phosphorus level 1.23 mM was discovered with very high PTH levels (863 ng/l; N<78). MIBI scintigraphy localized a right inferior parathyroid tumour. No obvious sign favouring MEN1 was observed and no familial case was reported. After a short pa...

Usual metastatic localizations in MTC are liver, bone and lung. We report two cases with metastases in pancreas and breast.In a 51-year-old woman were discovered several nodules in the thyroid gland: 29×19 mm in the right lobe and 5 mm in the left. Calcitonine (CT) levels were 2300 and ECA 44 ng/ml. Fine-needle aspiration of the main nodule confirmed MTC. Total thyroidectomy and right jugulo carotidal lymph node dissection were performed in 1998 wit...

A 14 year-old Turkish boy sought advice for growth retardation. Pituitary insufficiency with GH, TSH, ACTH and gonadotrophin defect was diagnosed and treated. He was born from a consanguineous family and was married at 24. Three years later he consulted wishing to father a child. He was treated with levothyroxine 150 μg, hGH 0,5 mg/day, hydrocortisone 20 mg/day and was switched from testosterone enantate to hCG+FSH. Azoospermia was initially found and oligospermia after t...

Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is one of the most frequent endocrine genetic diseases. Adrenal rests have been described and can decrease fertility in men1. In a retrospective multi-center study we wanted 1.to evaluate the frequency of adrenal rests in classical forms of CAH (21-OH deficiency) by systematic ultrasonography (US); 2.to try to find the cause of this abnormality looking for a relationship between genotype and pheno...